Background

Clinical

Intraglandular Off-the-Shelf Allogeneic Mesenchymal Stem Cell Treatment in Patients with Radiation-Induced Xerostomia: A Safety Study (MESRIX-II).
Lynggaard CD, Grønhøj C, Christensen R, Fischer-Nielsen A, Melchiors J, Specht L, Andersen E, Mortensen J, Oturai P, Barfod GH, Haastrup EK, Møller-Hansen M, Haack-Sørensen M, Ekblond A, Kastrup J, Jensen SB, von Buchwald C.Stem Cells Transl Med. 2022 May 27;11(5):478-489. doi: 10.1093/stcltm/szac011.

Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease.
Møller-Hansen M, Larsen AC, Toft PB, Lynggaard CD, Schwartz C, Bruunsgaard H, Haack-Sørensen M, Ekblond A, Kastrup J, Heegaard S.Ocul Surf. 2021 Jan;19:43-52. doi: 10.1016/j.jtos.2020.11.013.

Rationale and design of the European multicentre study on Stem Cell therapy in IschEmic Non-treatable Cardiac diseasE (SCIENCE).
Paitazoglou C, Bergmann MW, Vrtovec B, Chamuleau SAJ, van Klarenbosch B, Wojakowski W, Michalewska-Włudarczyk A, Gyöngyösi M, Ekblond A, Haack-Sørensen M, Jaquet K, Vrangbaek K, Kastrup J; SCIENCE Investigators.Eur J Heart Fail. 2019 Aug;21(8):1032-1041. doi: 10.1002/ejhf.1412.

Rationale and Design of the First Double-Blind, Placebo-Controlled Trial with Allogeneic Adipose Tissue-Derived Stromal Cell Therapy in Patients with Ischemic Heart Failure: A Phase II Danish Multicentre Study.
Kastrup J, Schou M, Gustafsson I, Nielsen OW, Møgelvang R, Kofoed KF, Kragelund C, Hove JD, Fabricius-Bjerre A, Heitman M, Haack-Sørensen M, Lund LD, Johansen EM, Qayyum AA, Mathiasen AB, Ekblond A.Stem Cells Int. 2017;2017:8506370. doi: 10.1155/2017/8506370.

Cryopreserved Off-the-Shelf Allogeneic Adipose-Derived Stromal Cells for Therapy in Patients with Ischemic Heart Disease and Heart Failure-A Safety Study.
Kastrup J, Haack-Sørensen M, Juhl M, Harary Søndergaard R, Follin B, Drozd Lund L, Mønsted Johansen E, Ali Qayyum A, Bruun Mathiasen A, Jørgensen E, Helqvist S, Jørgen Elberg J, Bruunsgaard H, Ekblond A.Stem Cells Transl Med. 2017 Nov;6(11):1963-1971. doi: 10.1002/sctm.17-0040.

Cell2Cure has a license from Rigshospitalet, Copenhagen, to a proprietary ASC production technology platform. The ASC technology has an extensive publication background both clinically and preclinically.

Cell2Cure forsidebillede

Cell2Cure has a license from Rigshospitalet, Copenhagen, to a proprietary ASC production technology platform. The ASC technology has an extensive publication background both clinically and preclinically.

Research & Technology

Production and preclinical

GMP Compliant Production of a Cryopreserved Adipose-Derived Stromal Cell Product for Feasible and Allogeneic Clinical Use.
Haack-Sørensen M, Johansen EM, Højgaard LD, Kastrup J, Ekblond A.Stem Cells Int. 2022 Jun 20;2022:4664917. doi: 10.1155/2022/4664917.

Adipose-derived stromal cells increase the formation of collagens through paracrine and juxtacrine mechanisms in a fibroblast co-culture model utilizing macromolecular crowding.
Søndergaard RH, Højgaard LD, Reese-Petersen AL, Hoeeg C, Mathiasen AB, Haack-Sørensen M, Follin B, Genovese F, Kastrup J, Juhl M, Ekblond A.Stem Cell Res Ther. 2022 Jun 11;13(1):250. doi: 10.1186/s13287-022-02923-y.

The Initial Cardiac Tissue Response to Cryopreserved Allogeneic Adipose Tissue-Derived Mesenchymal Stromal Cells in Rats with Chronic Ischemic Cardiomyopathy.
Follin B, Hoeeg C, Højgaard LD, Juhl M, Lund KB, Døssing KBV, Bentsen S, Hunter I, Nielsen CH, Ripa RS, Kastrup J, Ekblond A, Kjaer A.Int J Mol Sci. 2021 Oct 29;22(21):11758. doi: 10.3390/ijms222111758.


Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells.

Juhl M, Follin B, Gad M, Larsen J, Kastrup J, Ekblond A.Stem Cells Int. 2020 Oct 26;2020:8868909. doi: 10.1155/2020/8868909.

Development of large-scale manufacturing of adipose-derived stromal cells for clinical applications using bioreactors and human platelet lysate.
Haack-Sørensen M, Juhl M, Follin B, Harary Søndergaard R, Kirchhoff M, Kastrup J, Ekblond A.Scand J Clin Lab Invest. 2018 Jul;78(4):293-300. doi: 10.1080/00365513.2018.1462082.

Culture expansion of adipose derived stromal cells. A closed automated Quantum Cell Expansion System compared with manual flask-based culture.
Haack-Sørensen M, Follin B, Juhl M, Brorsen SK, Søndergaard RH, Kastrup J, Ekblond A.J Transl Med. 2016 Nov 16;14(1):319. doi: 10.1186/s12967-016-1080-9.

Senescence and quiescence in adipose-derived stromal cells: Effects of human platelet lysate, fetal bovine serum and hypoxia.
Søndergaard RH, Follin B, Lund LD, Juhl M, Ekblond A, Kastrup J, Haack-Sørensen M.Cytotherapy. 2017 Jan;19(1):95-106. doi: 10.1016/j.jcyt.2016.09.006.

Comparison of clinical grade human platelet lysates for cultivation of mesenchymal stromal cells from bone marrow and adipose tissue.
Juhl M, Tratwal J, Follin B, Søndergaard RH, Kirchhoff M, Ekblond A, Kastrup J, Haack-Sørensen M.Scand J Clin Lab Invest. 2016;76(2):93-104. doi: 10.3109/00365513.2015.1099723.

 

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Cell2Cure ApS
Kajerødgård 9, 3460 Birkerød, Denmark

CONTACT US

Innobooster grant

SME Instrument grant

This project has received funding from the European Union’s SME Instrument, Horizon 2020 research and innovation programme under grant agreement No [H2020-SMEINST-868284_PRO-SCT]

Grand Solution Grant

Cell2Cure, as part of the consortium Clinical Stem cell Innovation and production Center, CSIC, receives funding from Innovation Fund Denmark.